Déployer des études de validation à grande échelle directement depuis des structures de soin (en)

Leveraging the Okeiro platform to scale real-world studies in transplant and advanced disease management

Healthcare systems face unprecedented challenges in bringing novel therapeutics to patients with advanced chronic diseases and those requiring transplantation. While clinical trials remain the gold standard for therapeutic development, they often fail to capture the complexities of real-world patient populations and care pathways. The Okeiro platform, currently deployed across hospital transplant centers, offers a revolutionary approach to bridge this gap by transforming routine clinical care into opportunities for real-world evidence (RWE) generation at scale. This article explores how Okeiro can accelerate the development of new indications and treatments for patients through streamlined, technology-enabled real-world studies.

The challenge: from clinical trials to Real-World implementation

The path from controlled clinical trials to effective real-world implementation remains fraught with challenges. Traditional research models:

• Exclude complex patients who represent the majority of the real-world population
• Operate in silos disconnected from routine clinical workflows
• Struggle to capture longitudinal outcomes beyond the study period
• Require substantial infrastructure that limits participation to academic centers
• Fail to leverage the wealth of data generated through standard care

For transplant and end-stage disease patients, these limitations are particularly problematic, as their complex care journeys rarely fit neatly into traditional research paradigms.

The Okeiro solution: embedding research in clinical care

Okeiro has established itself as a leading point-of-care platform for managing transplant and end-stage disease patients across hospital networks. Building on this foundation, Okeiro now offers a seamless pathway to conduct real-world studies at scale by:

1. Integrating research into existing clinical workflows: Unlike standalone research platforms, Okeiro embeds study protocols directly into the clinical care pathways already familiar to healthcare providers.

2. Leveraging existing data infrastructure: The platform taps into data already being collected as part of routine care, minimizing additional documentation burden.

3. Providing a pre-established network of sites and specialists: With deployment across transplant centers, Okeiro offers immediate access to specialized care teams and their patients.

4. Enabling longitudinal patient tracking: The platform's continuous patient monitoring capabilities allow for long-term outcome assessment beyond typical study endpoints.

From data to discovery

Precision patient identification

Okeiro's comprehensive patient profiles enable precise identification of eligible candidates for specific studies. The platform's analyze clinical parameters, treatment histories, and outcomes to identify potential participants who match study criteria.

By understanding the unique characteristics of each site's patient population, Okeiro can better match studies to the right clinical environments by providing real-time insights into transplant and end-stage disease populations across its network.

Integrated multimodal data collection

Okeiro aggregates diverse data types including:

• Clinical documentation
• Biological, Immunological, Histological and Genetic values
• Imaging results
• Medication administration data
• Patient-reported outcomes

This comprehensive data ecosystem creates a clinical-molecular database and operating system to deliver precision transplant medicine. This integrated approach is particularly valuable given the multifaceted nature of transplant patients

Paradigm shift

The Okeiro platform represents a paradigm shift in how we approach research in complex disease management. By leveraging existing clinical infrastructure, comprehensive data collection, and advanced analytics, Okeiro transforms the traditional research model into a seamless extension of patient care. For patients with transplant and end-stage diseases, this integrated approach promises to accelerate access to novel therapies and optimize existing treatment pathways.

As we look to the future, the line between clinical care and clinical research will continue to blur. Platforms like Okeiro that bridge this gap will be essential to bringing innovative treatments to patients more quickly and effectively than ever before.